Prozac: Side Effects for Women

The sexual side effects of Prozac and how to deal with them

"My libido is down and I've recently started taking Prozac (Fluoxetine). Are the two related?"

Yes, decreased libido or sex drive is a very common side effect of this popular drug. In fact, 11% of patients, both male and female, reported this symptom. There are several other side effects of Prozac in women as well.

You might consider switching to Zoloft. It has a lower side effect profile, overall. Although it does still have the problems with decreased libido, it is possible to get around this because it stays in the body a shorter amount of time it is possible to take a "drug holiday." If you discontinue the drug for a weekend (2-4 days), your normal sex drive and response will return, quickly. The drug can be resumed after short periods without a loss of clinical effectiveness.

Other Side Effects of Prozac Unique to Women

Prozac is used in depression and obsessive/compulsive disorders. Both of these are more common in women, so it is more likely women will be on the drug.


Infrequent is defined as 1 out of 100 (or 1%) to 1 out of 1000 (.1%):

  • Amenorrhea (lack of menstruation)

  • Breast Pain

  • Fibrocystic Breast

  • Leukorrhea (white or yellow discharge from the vagina)

  • Menopause

  • Menorrhagia (Excessive menstrual bleeding)

  • Ovarian disorder


Rare was defined less than 1 out of 1000 (.1%):

  • Abortion (spontaneous loss of a pregnancy or conception)

  • Breast Enlargement

  • Dyspareunia (Pain during intercourse)

  • Lactation (Milk production from the breasts)

  • Hypomenorrhea (Decreased menstrual bleeding)

  • Metrorrhagia (bleeding between periods)

  • Salpingitis (Inflammation of the Fallopian tubes, which carry the egg from the ovary to the uterus)

Pregnancy, Breastfeeding, and Prozac

Prozac is a Class B drug for pregnancy. That means that the drug should be taken in pregnancy only if it is clearly needed. Inform your doctor is you are, plan to be, or do become pregnant on Prozac. The same applies to breastfeeding.

APA Reference
Staff, H. (2021, December 21). Prozac: Side Effects for Women, HealthyPlace. Retrieved on 2024, July 14 from

Last Updated: March 26, 2022

Medically reviewed by Harry Croft, MD

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