Unfortunately, some 1/3 of depression patients don't get relief even after trying 2-4 antidepressant medications. HealthyPlace.com Medical Director, Dr. Harry Croft, says there are several reasons behind tough-to-treat depression and provides additional depression treatment options. For comprehensive information on depression, visit the HealthyPlace.com Depression Information Center: http://www.healthyplace.com/depression/menu-id-68/