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Five (or more) of the following symptoms have been present during
the same 2-week period and represent a change from previous
functioning; at least one of the symptoms is either: (1) depressed
mood or (2) loss of interest or pleasure. (Note: Do not include
symptoms that are clearly due to a general medical condition, or
mood-incongruent delusions or hallucinations.)
- depressed mood most of the day, nearly every day, as indicated
by either subjective report (e.g., feels sad or empty) or
observation made by others (e.g., appears tearful). Note: In
children and adolescents, can be irritable mood.
- markedly diminished interest or pleasure in all, or almost
all, activities most of the day, nearly every day (as indicated
by either subjective account or observation made by others)
- significant weight loss when not dieting or weight gain (e.g.,
a change of more than 5% of body weight in a month), or decrease
or increase in appetite nearly every day. Note: In children,
consider failure to make expected weight gains.
- insomnia or hypersomnia nearly every day
- psychomotor agitation or retardation nearly every day
(observable by others, not merely subjective feelings of
restlessness or being slowed down)
- fatigue or loss of energy nearly every day
- feelings of worthlessness or excessive or inappropriate guilt
(which may be delusional) nearly every day (not merely
self-reproach or guilt about being sick)
- diminished ability to think or concentrate, or indecisiveness,
nearly every day (either by subjective account or as observed by
others)
- recurrent thoughts of death (not just fear of dying),
recurrent suicidal ideation without a specific plan, or a
suicide attempt or a specific plan for committing suicide
The symptoms cause clinically significant distress or impairment
in social, occupational, or other important areas of functioning.
The symptoms are not due to the direct physiological effects of a
substance (e.g., a drug of abuse, a medication) or a general medical
condition (e.g., hypothyroidism).
The symptoms are not better accounted for by Bereavement, i.e.,
after the loss of a loved one, the symptoms persist for longer than
2 months or are characterized by marked functional impairment,
morbid preoccupation with worthlessness, suicidal ideation,
psychotic symptoms, or psychomotor retardation.
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